2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Ser/Thr Protease

Ser/Thr Protease

Serine proteases; Serine endopeptidases; Threonine proteases

Ser/Thr Protease

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Serine (Ser) proteases catalyse the hydrolysis of specific peptide bonds in their substrates and this activity depends on a set of amino acids in the active site of the enzyme, one of which is always a serine. There are two families especially well studied, the trypsin family and the subtilisin family. Serine proteases play crucial roles in a wide variety of cellular as well as extracellular functions, including the process of blood clotting, protein digestion, cell signaling, inflammation, and protein processing. Threonine (Thr) proteases are a family of proteolytic enzymes harbouring a threonine residue within the active site. The prototype members of this class of enzymes are the catalytic subunits of the proteasome, however the acyltransferases convergently evolved the same active site geometry and mechanism.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-P11367
    Boc-Ala-Gly-Pro-Arg-AMC
    Boc-Ala-Gly-Pro-Arg-AMC is a synthetic fluorescent substrate, widely used for the detection of protease activity. Boc-Ala-Gly-Pro-Arg-AMC can be used to detect the activity of serine proteases and the oligopeptide enzyme B of Trypanosoma brucei.
    Boc-Ala-Gly-Pro-Arg-AMC
  • HY-167924
    Ono 3307 free base
    Ono 3307 Free base is a novel synthetic protease inhibitor that exhibits protective effects against acute pancreatitis by preventing hyperamylasemia and pancreatic edema. Ono 3307 Free base also inhibits the redistribution of lysosomal enzymes in acinar cells and mitigates lactic dehydrogenase discharge. Ono 3307 Free base effectively reduces cathepsin B leakage from lysosomes in a dose-dependent manner. Ono 3307 Free base is able to target trypsin (Ki=48 nM), thrombin (Ki=0.18 μM), plasma kallikrein (Ki=0.29 μM), plasmin (Ki=0.31 μM), pancreatic kallikrein (Ki=3.6 μM), and chymotrypsin (Ki=47 μM).
    Ono 3307 free base
  • HY-P4528
    Ala-Phe-Pro-βNA
    Ala-Phe-Pro-βNA is the subsrate of prolyl tripeptidyl aminopeptidase, which is from Porphyromonas gingivalis. Ala-Phe-Pro-βNA binds to H-Ala-Ile-pyrrolidin-2-yl boronic acid for PTP39 and the E636A mutant with Ki values of 88.1 nM and 48.8 nM, respectivley.
    Ala-Phe-Pro-βNA
  • HY-E70586
    Elastase (high purity)
    Elastase (high purity) is a serine protease that hydrolyzes proteins and peptides.
    Elastase (high purity)
  • HY-P4366
    Tos-Gly-Pro-Lys-AMC
    Tos-Gly-Pro-Lys-AMC is a fluorogenic peptide substrate of tryptase.
    Tos-Gly-Pro-Lys-AMC
  • HY-145292
    TNIK-IN-2
    		Inhibitor 99.68%
    TNIK-IN-2 is a Traf2- and Nck-interacting protein kinase (TNIK) inhibitor, with an IC50 of 1.3337 μM. TNIK-IN-2 can be used for the study of colorectal cancer (CRC).
    TNIK-IN-2
  • HY-16511AS
    (E)-Upamostat-d5
    		Inhibitor
    (E)-Upamostat-d5 ((E)-WX-671-d5) is the deuterium labeled (E)-Upamostat (HY-16511A). (E)-Upamostat ((E)-WX-671) is an E-isomer of Upamostat (HY-16511). Upamostat (WX-671), a prodrug of WX-UK1, is an orally active serine protease inhibitor.
    (E)-Upamostat-d<sub>5</sub>
  • HY-182450
    WX-293
    		Inhibitor
    WX-293 is a highly selective urokinase-type plasminogen activator (uPA) inhibitor with a Ki value of 2.4 μM. WX-293 abolishes hypoxia-induced keratinocyte migration and in vitro wound closure. WX-293 can be used in research on hypoxia-mediated skin wounds and solid malignant tumors.
    WX-293
  • HY-P4332
    Boc-Glu(OBzl)-Ala-Arg-AMC
    		Substrate
    Boc-Glu(OBzl)-Ala-Arg-AMC is a fluorogenic substrate for coagulation factor XIa and trypsin. The cleavage of the amide bond between arginine and the methylcoumarin amide group releases fluorescent 7-Amino-4-methylcoumarin (HY-D0027).
    Boc-Glu(OBzl)-Ala-Arg-AMC
  • HY-P990533
    Anti-TPSAB1 Antibody
    Anti-TPSAB1 Antibody is a CHO-expressed human antibody that targets TPSAB1. The Anti-TPSAB1 Antibody has a huIgG4SP type heavy chain and a huκ type light chain, with a predicted molecular weight (MW) of 150 kDa. The isotype control for the Anti-TPSAB1 Antibody can be referenced as Human IgG4 kappa, Isotype Control (HY-P99003).
    Anti-TPSAB1 Antibody
  • HY-143867
    Kallikrein-IN-2
    		Inhibitor
    Kallikrein-IN-2 (compound 1) is a Kallikrein inhibitor.
    Kallikrein-IN-2
  • HY-P990431
    Anti-HGFA Antibody
    		Inhibitor
    Anti-HGFA Antibody is a humanized antibody expressed in CHO cells, targeting HGFA. The Anti-HGFA Antibody contains huIgG1 heavy chain and huκ light chain, with a predicted molecular weight (MW) of 150 kDa. The isotype control for Anti-HGFA Antibody can refer to Human IgG1 kappa, Isotype Control (HY-P99001).
    Anti-HGFA Antibody
  • HY-P11335
    Oscillamide Y
    		Inhibitor
    Oscillamide Y (Compound 1), a ureido-containing cyclic peptide, is a Chymotrypsin inhibitor. Oscillamide Y can be isolated from freshwater toxic cyanobacterium Oscillatoria agardhii. Oscillamide Y has potent toxicity against fish, daphnid magna and algae with a stimulatory effect for Raphidocelis subcapitata (EC50: 4.62 mg/L). Oscillamide Y induces high luminescence inhibition in Aliivibrio fischeri. Oscillamide Y can be used for ecological development research.
    Oscillamide Y
  • HY-P5377
    Abz-HPGGPQ-EDDnp
    Abz-HPGGPQ-EDDnp (Cathepsin K substrate) is a biological active peptide. (Cathepsins are a class of globular lysosomal proteases, playing a vital role in mammalian cellular turnover. They degrade polypeptides and are distinguished by their substrate specificities. Cathepsin K is the lysosomal cysteine protease involved in bone remodeling and resorption. It has potential as a drug target in autoimmune diseases and osteoporosis.This FRET peptide can be used to monitor selectively cathepsin K activity in physiological fluids and cell lysates. Abz-HPGGPQ-EDDnp [where Abz represents o-aminobenzoic acid and EDDnp represents N -(2, 4-dinitrophenyl)-ethylenediamine], a substrate initially developed for trypanosomal enzymes, is efficiently cleaved at the Gly-Gly bond by cathepsin K. This peptide is resistant to hydrolysis by cathepsins B, F, H, L, S and V, Ex/Em=340 nm/420 nm.)
    Abz-HPGGPQ-EDDnp
  • HY-182414
    NCO-650 free base
    		Inhibitor
    NCO-650 free base is an antiallergic agent that acts by inhibiting tryptase, a key trypsin-like protease in mast cells. NCO-650 free base inhibits mast cell histamine release, increases intracellular cAMP levels in mast cells, suppresses bronchoconstriction, and prevents decreases in perfusion pressure and systemic blood pressure. NCO-650 free base is applicable to the research of allergic diseases and bronchial asthma.
    NCO-650 free base
  • HY-16512
    Upamostat hydrogen sulfate
    		Inhibitor
    Upamostat (WX-671) hydrogen sulfate, a prodrug of WX-UK1 (HY-100415), is an orally active serine protease inhibitor. Upamostat hydrogen sulfate inhibits the urokinase-type plasminogen activator (uPA) system, blocking the plasminogen activation process mediated by it, thereby suppressing the invasion, migration and metastasis of tumor cells. Upamostat hydrogen sulfate can be used in the research of metastatic breast cancer and locally advanced pancreatic cancer.
    Upamostat hydrogen sulfate
  • HY-15958A
    (S,R,R)-VBY-825
    		98.01%
    (S,R,R)-VBY-825 is the isomer of VBY-825 (HY-15958), and can be used as an experimental control. VBY-825 is a novel reversible inhibitor of cathepsin with high inhibition of cathepsin B, L, S and V.
    (S,R,R)-VBY-825
  • HY-N4333
    Rivulariapeptolides 988
    Rivulariapeptolides 988 is a high potent and selective serine protease inhibitor with IC50 values of 95.46 nM, 15.29 nM and 85.50 nM for chymotrypsin, elastase and proteinase K, respectively.
    Rivulariapeptolides 988
  • HY-16511A
    (E)-Upamostat
    		Inhibitor
    (E)-Upamostat ((E)-WX-671) is an E-isomer of Upamostat (HY-16511). Upamostat (WX-671), a prodrug of WX-UK1, is an orally active serine protease inhibitor.
    (E)-Upamostat
  • HY-P992463
    SHR-2010
    		Inhibitor
    SHR-2010 is a fully humanized monoclonal antibody targeting MASP-2. SHR-2010 selectively inhibits lectin pathway activation without affecting classical or alternative complement pathways. SHR-2010 can be used for the research of IgA nephropathy.
    SHR-2010
Cat. No. Product Name / Synonyms Application Reactivity